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Grain Brain-The Surprising Truth About Wheat Carbs and Sugar Your Brain's Silent Killers- By David Perlmutter, MD

  • Writer: John Wilson
    John Wilson
  • 3 days ago
  • 3 min read

Wheat, carbs, and sugar have become staples in most of our diets, yet recent research reveals they may silently harm your brain. Dr. David Perlmutter, a neurologist with a background in nutrition, challenges the common belief that low-fat, high-carb diets are healthy. His book Grain Brain exposes how these foods contribute to brain diseases, including dementia, which is now called type 3 diabetes. Understanding these hidden dangers can help you protect your brain and overall health.


Close-up view of wheat grains on a wooden surface
Grain Brain by David Perlmutter, MD

How Wheat and Gluten Affect the Brain


Wheat today contains much more gluten than it did in the past. It is estimated that this increase affects nearly half of the global population, as it is estimated that over 46% of people show some sensitivity to gluten. Gluten sensitivity can cause inflammation not only in the gut but also in the brain. This inflammation may lead to cognitive issues, mood disorders, and even contribute to neurodegenerative diseases. Not only do people have a tendency to show sensitivity to gluten, there are multiple proteins in wheat that can trigger inflammation.


Dr. Perlmutter explains that many patients who removed wheat from their diets experienced improvements in memory, focus, and mood. This suggests that gluten and wheat may play a larger role in brain health than previously thought. The rise in gluten-related problems coincides with the increase in processed wheat products and refined carbohydrates in modern diets.


The Role of Refined Carbohydrates and Sugar in Brain Inflammation


Refined carbs and sugar cause spikes in blood sugar levels, which trigger systemic inflammation throughout the body. This inflammation affects the brain’s ability to function properly. Chronic inflammation is linked to insulin resistance, a key factor in metabolic syndrome and type 2 diabetes. These conditions increase the risk of cognitive decline and dementia.


Sugar consumption has skyrocketed in recent decades, paralleling the rise in brain diseases. Dr. Perlmutter highlights that sugar and refined carbs feed harmful bacteria and promote inflammation, which can damage brain cells and impair communication between neurons. Eliminating sugar and refined carbohydrate intake can help lower inflammation and support brain repair.


Why Low-Fat Diets May Harm Brain Health


For years, low-fat diets were promoted as the healthiest option. However, the brain needs healthy fats to repair itself and maintain function, in fact the nervous system and every cell in the body does. Fat is a critical component of brain cells and supports the production of neurotransmitters, as well as hormones. Without enough fat, the brain struggles to heal and maintain its structure.


Dr. Perlmutter points out that depriving the brain of fat while increasing carbs and sugar creates a perfect storm for brain disease. Instead of protecting the brain, low-fat diets may contribute to cognitive decline by limiting essential nutrients. Including healthy fats like omega-3s from fish, all animal fats, butter and some oils support brain health and reduce inflammation.



Practical Steps to Protect Your Brain


Based on the research presented in Grain Brain, here are some practical steps to support your brain health:


  • Eliminate wheat and gluten: Try eliminating wheat products, especially processed ones, to see if your cognitive function improves.

  • Cut back on sugar and refined carbs: Replace sugary snacks and white bread with whole foods like vegetables, and meat.

  • Include healthy fats: Add sources of omega-3 fatty acids such as fish along with meat, eggs and butter.

  • Focus on nutrient-dense foods: Non starchy vegetables and healthy fats provide the nutrients your brain needs to repair and function well.

  • Monitor your body's response: Everyone’s sensitivity varies, so pay attention to how your brain and body feel after dietary changes.


Understanding Dementia as Type 3 Diabetes


Dr. Perlmutter, like many scientists currently, refers to dementia as type 3 diabetes because of the strong link between insulin resistance and brain disease. Insulin resistance in the brain impairs glucose metabolism, which is essential for brain energy. When the brain cannot use glucose efficiently, cognitive decline accelerates. This coupled with brain inflammation is a slow acting form of brain damage that can result in many neurological disorders, and surface decades later. Type 2 diabetics are twice as likely to develop dementia later in life. More so, Perlmutter explains that the plaques in the brain that are blamed for causing Alzheimer's disease are prevented from forming in a healthy individual with no inflammation.


This connection highlights the importance of managing blood sugar levels not only for physical health but also for mental sharpness. Diet plays a crucial role in preventing insulin resistance and protecting brain function. Systemic inflammation can take many forms, and surface as many different diseases in the brain and the rest of the body. David Perlmutter combines his knowledge of modern research and his many years of medical practice to bring us this important message. I would recommend this book to everyone, at no time in history has it been more relevant.



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